Can Molecular and Cellular Neuroprotection Be Translated Into Therapies for Patients?: Yes, but Not the Way We Tried It Before

Can molecular and cellular neuroprotection be translated into therapies for patients?: yes, but not the way we tried it before.

BACKGROUND AND PURPOSE The concept of neuroprotection is based on sound scientific data derived in preclinical studies. However, candidate neuroprotectants have never been successfully translated to patients. METHODS A review of past approaches to cellular and molecular neuroprotection, preclinical neuroprotection studies, and clinical approaches was undertaken. RESULTS Although there is no...

Yes we can, but do we?

In recent decades, a curious demographic phenomenon has emerged in US science. A high and increasing proportion of PhD students and postdocs, especially in the life sciences, are drawn from beyond the shores of North America. The reasons for this are undoubtedly complex. One factor is the widespread perception in the USA that a career in academic science is marked by low salaries, poor job secu...

Chemotherapy in elderly small-cell lung cancer patients: yes we can, but should we do it?

BACKGROUND Twenty percent of all newly diagnosed patients with small-cell lung cancer (SCLC) are >75 years. Elderly patients may show more toxicity due to co-morbidity. We evaluated motives for adherence to treatment guidelines, completion of treatment and toxicity. PATIENTS AND METHODS Population-based data from patients aged ≥75 years and diagnosed with SCLC in 1997-2004 in The Netherlands ...

“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries

When Can We Lift the Coronavirus Pandemic Restrictions? Not Before Taking These Steps

When Can We Lift the Coronavirus Pandemic Restrictions? Not Before Taking These Steps. The American Enterprise Institute, a public policy think tank, recently released a report co-written by former U.S. Food and Drug Administration commissioner Scott Gottlieb that offers a four-phase “road map to reopening.” The first phase involves slowing the spread of new infections with physical distancing ...